DISEASE PREVENTION FUNCTIONAL FOODS FROM THE HIGH P OTENTIAL MMP-2 INHIBITION ACTIVITY OF PINEAPPLE JUICE GRANULE
By: Ruksiriwanich, Warintorn
.
Contributor(s): Chaitep, Tanakarn.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(4).Description: 16-22p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
This study aimed to compare total phenolic acid and
protein contents as well as free radical scavengin
g, enzyme activities of fresh and
fermented pineapple juice
.
Methods:
The dried pineapple juice, prepared by freeze-dryin
g and granulation method, with high bioactive compo
unds (total phenolic acid and
protein contents) and biological activities (scaven
ging and enzyme activities) from fresh and fermente
d pineapple juice was developed and
evaluated. The selected granules were evaluated
for their stability at the 3 different temperatures
for 3 mo. The pineapple juice granules were
tested for the non-cytotoxic concentration by the S
RB assay and Matrix metalloproteinase 2 (MMP-2) inh
ibition activity on human skin fibroblast.
Results:
The pineapple juice granules,
the single
-
coated granules
of pineapple juice showed a higher percentage of yi
eld but lower biological
contents and activities than that
triple
-
coated
granules
.
The triple
-
coated granules
of pineapple juice exhibited the highest total prot
ein content
(1.53±0.10 mg Bovine serum albumin equivalent (BSAE
))
with scavenging activity
(51.15
±
5.94 %)
, and enzyme activity
(4156.18
±
74.78
Casein
digestion unit (CDU)
/
mg
).
For gelatinolytic activity
on MMP-2, the freeze-dried powder and triple-coated
granules of pineapple juice indicated the
highest MMP-2 inhibition activity of 50.74% and 48.
48%, respectively.
Conclusion:
The triple-coated granules of pineapple juice could
be served as a disease prevention functional food
due to its easy operation, high
total phenolic acid, and protein contents with high
potential MMP-2 inhibition activity.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020902 |
Objective:
This study aimed to compare total phenolic acid and
protein contents as well as free radical scavengin
g, enzyme activities of fresh and
fermented pineapple juice
.
Methods:
The dried pineapple juice, prepared by freeze-dryin
g and granulation method, with high bioactive compo
unds (total phenolic acid and
protein contents) and biological activities (scaven
ging and enzyme activities) from fresh and fermente
d pineapple juice was developed and
evaluated. The selected granules were evaluated
for their stability at the 3 different temperatures
for 3 mo. The pineapple juice granules were
tested for the non-cytotoxic concentration by the S
RB assay and Matrix metalloproteinase 2 (MMP-2) inh
ibition activity on human skin fibroblast.
Results:
The pineapple juice granules,
the single
-
coated granules
of pineapple juice showed a higher percentage of yi
eld but lower biological
contents and activities than that
triple
-
coated
granules
.
The triple
-
coated granules
of pineapple juice exhibited the highest total prot
ein content
(1.53±0.10 mg Bovine serum albumin equivalent (BSAE
))
with scavenging activity
(51.15
±
5.94 %)
, and enzyme activity
(4156.18
±
74.78
Casein
digestion unit (CDU)
/
mg
).
For gelatinolytic activity
on MMP-2, the freeze-dried powder and triple-coated
granules of pineapple juice indicated the
highest MMP-2 inhibition activity of 50.74% and 48.
48%, respectively.
Conclusion:
The triple-coated granules of pineapple juice could
be served as a disease prevention functional food
due to its easy operation, high
total phenolic acid, and protein contents with high
potential MMP-2 inhibition activity.
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